Journal article
Mammographic texture features associated with contralateral breast cancer in the WECARE Study
GP Watt, JA Knight, C Lin, CF Lynch, KE Malone, EM John, L Bernstein, JD Brooks, AS Reiner, X Liang, M Woods, TL Nguyen, JL Hopper, MC Pike, JL Bernstein
Npj Breast Cancer | NATURE PORTFOLIO | Published : 2021
Open access
Abstract
To evaluate whether mammographic texture features were associated with second primary contralateral breast cancer (CBC) risk, we created a “texture risk score” using pre-treatment mammograms in a case–control study of 212 women with CBC and 223 controls with unilateral breast cancer. The texture risk score was associated with CBC (odds per adjusted standard deviation = 1.25, 95% CI 1.01–1.56) after adjustment for mammographic percent density and confounders. These results support the potential of texture features for CBC risk assessment of breast cancer survivors.
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Grants
Awarded by National Cancer Institute
Funding Acknowledgements
The authors would like to thank the participants of the WECARE Study for making this work possible. This work was supported by the United States National Cancer Institute award numbers R01 CA168339, R01 CA97397, P30 CA008748, U01 CA83178, R01 CA129649, R01 CA129639, R01 CA114236, and P30CA086862; by the Victoria Cancer Council award numbers 1139144 and TP900783; and by the Cure Cancer Australia Foundation award number 1159399.